Acceleration of wound healing by alpha-gal nanoparticles interacting with the natural anti-Gal antibody
نویسنده
چکیده
This work is licensed under a Creative Commons Attribution 3.0 License. Galili, Uri, "Acceleration of wound healing by alpha-gal nanoparticles interacting with the natural anti-Gal antibody" (2015).
منابع مشابه
Acceleration of Wound Healing by α-gal Nanoparticles Interacting with the Natural Anti-Gal Antibody
Application of α-gal nanoparticles to wounds and burns induces accelerated healing by harnessing the natural anti-Gal antibody which constitutes ~1% of human immunoglobulins. α-gal nanoparticles present multiple α-gal epitopes (Galα1-3Galβ1-4GlcNAc-R), the carbohydrate ligand of anti-Gal. Studied α-gal nanoparticles were comprised of glycolipids with α-gal epitopes, phospholipids, and cholester...
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Macrophages are pivotal in promoting wound healing. We hypothesized that topical application of liposomes with glycolipids that carry Galα1-3Galβ1-4GlcNAc-R epitopes (α-gal liposomes) on wounds may accelerate the healing process by rapid recruitment and activation of macrophages in wounds. Immune complexes of the natural anti-Gal Ab (constituting ∼1% of Ig in humans) bound to its ligand, the α-...
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